2013—2022年河北省单核细胞增生李斯特菌的临床分布及耐药性

目的 回顾性分析2013—2022年河北省细菌耐药监测网75所医院单核细胞增生李斯特菌的分布及耐药性,为临床治疗及合理使用抗菌药物提供依据。 方法 应用WHONET软件对2013年1月—2022年6月河北省75所医院临床分离的单核细胞增生李斯特菌的标本来源、科室分布及耐药性进行分析。 结果 2013—2022年河北省共检出187株单核细胞增生李斯特菌,分离标本主要为血(129株,69.0%)、脑脊液(20株,10.7%)、胃液(14株,7.5%)及其他(18株,9.6%);70株(37.4%)分离自男性,117株(62.6%)分离自女性;新生儿科(42株,22.5%)和妇产科(41株,21.9%)为最常见的来源科室;年龄分组上,青年人(74株,39.6%)最多,其次为新生儿(39株,20.9%)。该菌对青霉素、氨苄西林、美罗培南、复方磺胺甲唑和红霉素的敏感率分别为97.8%、98.6%、98.0%、98.4%和96.3%。 结论 2013—2022年河北省临床分离的单核细胞增生李斯特菌大多来源于血标本,感染人群以青年和新生儿为主,该菌已出现一线治疗药物的非敏感株,需持续关注。

Clinical distribution and antimicrobial resistance of Listeria monocytogenes in Hebei Province from 2013 to 2022

Objective To retrospectively analyze the distribution and antimicrobial resistance of Listeria monocytogenes (L. monocytogenes) in 75 hospitals using the data from Hebei Provincial Bacterial Resistance Monitoring System from 2013 to 2022, and to provide a basis for clinical treatment and rational use of antimicrobial agents. Methods Specimen sources, department distribution, and antimicrobial resistance of L. monocytogenes isolated from clinical cases in 75 hospitals in Hebei Province from January 2013 to June 2022 were analyzed with WHONET software. Results From 2013 to 2022, a total of 187 strains of L. monocytogenes were isolated in Hebei Province. The specimens were mainly blood (129 strains, 69.0%), cerebrospinal fluid (20 strains, 10.7%), gastric fluid (14 strains, 7.5%), and others (18 strains, 9.6%). 70 (37.4%) strains were isolated from males, and 117 (62.6%) were from females. Department of neonatology (42 strains, 22.5%) as well as department of obstetrics and gynecology (41 strains, 21.9%) were the most common sources. In terms of age groups, young adults had the highest isolation rate (74 strains, 39.6%), followed by neonates (39 strains, 20.9%). The susceptibility rates of the strains to penicillin, ampicillin, meropenem, compound sulfamethoxazole and erythromycin were 97.8%, 98.6%, 98.0%, 98.4% and 96.3%, respectively. Conclusion From 2013 to 2022, most L. monocytogenes strains isolated from clinical cases in Hebei Province were from blood specimen, and the infected population were mainly young adults and neonates. Non-susceptible strains to first-line antimicrobials have emerged and continuous attention is needed.