噬菌体在医院感染防控中的研究进展

目前医院感染预防与控制面临着许多亟待解决的问题, 多重耐药菌防控的有效性、生物膜的有效清除、水源性传播病原体的鉴定与防控、环境物体表面消毒的持续有效性等都对医院感染防控提出了更高的要求。噬菌体是侵袭细菌的病毒, 也可以传递赋予宿主菌生物学性状的遗传物质。噬菌体在降低多重耐药菌和清除生物膜中所展示出的特异性和有效性, 使其具有成为医院感染防控新方法的潜力。本综述总结噬菌体在医院感染防控中的相关研究, 包括在对抗多重耐药菌、清除生物膜方面的优势, 以及在医院感染病例识别、环境清洁消毒、水源性传播防控和医院综合管理中的应用。

Research progress of bacteriophages in the prevention and control of healthcare-associated infection

Currently, many urgent issues in the prevention and control of healthcare-associated infection (HAI) need to be solved. The effectiveness of the prevention and control of multidrug-resistant organisms (MDROs), the effective removal of biofilms, the identification, prevention and control of water-borne pathogens, and the persis-tence of surface disinfection of environmental objects all pose higher requirements for the prevention and control of HAI. Bacteriophages are viruses that invade bacteria, and can also transmit genetic materials that confer biological traits on the host bacteria. The specificity and effectiveness of bacteriophages in reducing MDROs and clearing biofilms make them potentially a new approach to HAI prevention and control. This review summarizes researches related to the application of bacteriophages in HAI prevention and control, including their advantages in combating MDROs and clearing biofilms, as well as their applications in the identification of HAI cases, environmental cle a-ning and disinfection, prevention and control of water-borne transmission, and comprehensive hospital management.