| 病理性瘢痕组织中基质金属蛋白酶-1、金属蛋白酶组织抑制剂-1、血小板源性生长因子、增殖细胞核抗原的表达 |
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| 引用本文： | 郭丽丽,陈言汤,牛扶幼,刘林嶓. 病理性瘢痕组织中基质金属蛋白酶-1、金属蛋白酶组织抑制剂-1、血小板源性生长因子、增殖细胞核抗原的表达[J]. 郑州大学学报(医学版), 2006, 41(6): 1027-1030 |
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| 作者姓名： | 郭丽丽 陈言汤 牛扶幼 刘林嶓 |
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| 作者单位： | 郑州大学第一附属医院整形外科,河南省高等学校临床医学重点学科开放实验室,郑州,450052;郑州大学第一附属医院整形外科,河南省高等学校临床医学重点学科开放实验室,郑州,450052;郑州大学第一附属医院整形外科,河南省高等学校临床医学重点学科开放实验室,郑州,450052;郑州大学第一附属医院整形外科,河南省高等学校临床医学重点学科开放实验室,郑州,450052 |
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| 摘 要： | 目的:探讨病理性瘢痕组织中基质金属蛋白酶-1(MMP-1)、金属蛋白酶组织抑制剂-1(TIMP-1)、血小板源性生长因子(PDGF)、增殖细胞核抗原(PCNA)的表达及意义.方法:采用免疫组织化学方法检测58例病理性瘢痕、16例正常皮肤及16例非病理性瘢痕组织中MMP-1、TIMP-1、PDGF及PCNA的表达情况.结果:病理性瘢痕组织中MMP-1、TIMP-1、PDGF阳性表达率及PCNA指数均高于非病理性瘢痕及正常皮肤组织(P均＜0.05).病理性瘢痕组织中TIMP-1与PDGF、MMP-1、PCNA及PDGF与PCNA表达均呈正相关(P均＜0.05).结论:病理性瘢痕的形成与MMP-1、TIMP-1、PDGF及PCNA相互作用失衡有关.
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| 关 键 词： | 增生性瘢痕 瘢痕疙瘩 基质金属蛋白酶-1 金属蛋白酶组织抑制剂-1 血小板源性生长因子 增殖细胞核抗原 |
| 收稿时间： | 2005-11-15 |
| 修稿时间： | 2005-11-15 |
Expression of matrix metalloproteinase-1, tissue inhibitor of metalloproteinase-1, platelet-derived growth factor, and proliferating cell nuclear antigen in pathologic scar tissue |
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| GUO Lili,CHEN Yantang,NIU Fuyou,LIU Linbo. Expression of matrix metalloproteinase-1, tissue inhibitor of metalloproteinase-1, platelet-derived growth factor, and proliferating cell nuclear antigen in pathologic scar tissue[J]. Journal of Zhengzhou University: Med Sci, 2006, 41(6): 1027-1030 |
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| Authors: | GUO Lili CHEN Yantang NIU Fuyou LIU Linbo |
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| Affiliation: | Department of Plastic Surgery, the First Affiliated Hospital, Zhengzhou University; Henan Key Laboratory of Clinical Medicine, Zhengzhou 450052 |
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| Abstract: | Aim: To study the expression of matrix metalloproteinase-1(MMP-1), tissue inhibitor of metalloproteinase-1(TIMP-1), platelet-derived growth factor (PDGF), and proliferating cell nuclear antigen (PCNA) in pathologic scar. Methods: The expressions of MMP-1, TIMP-1, PDGF, and PCNA were detected using immunohistochemistry in 58 cases of pathologic scar, 16 cases of normal skin, and 16 cases of normotrophic scar.Results: The positive rates of MMP-1, TIMP-1, and PDGF and the proliferation index of PCNA in pathologic scar were higher than those in normal skin and normotrophic scar (P<0.05). There were positive correlation between TIMP-1 and PDGF, TIMP-1 and MMP-1, TIMP-1 and PCNA, PDGF and PCNA (P<0.05). Conclusion: The formation of pathologic scar is correlated with the imbalance of interaction among MMP-1, TIMP-1, PDGF, and PCNA. |
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| Keywords: | hypertrophic scar keloid matrix matalloproteinase-1 tissue inhibitor of metalloproteinase-1 platelet-derived growth factor proliferating cell nuclear antigen |
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