Comparative activity of linezolid against staphylococci and enterococci isolated in Italy |
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Authors: | S Stefani M L Mezzatesta G Tempera E Debbra A M Schito G Nicoletti A Marchére |
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Institution: | Department of Microbiological and Gynecologic Sciences, Section of Microbiology, University of Catania, Via Androne 81, 95124 Catania and;DISCAT, Section of Microbiology, Universities of Catania and Genoa, Italy.; Tel: +39 095311352 Fax: +39 095325032 E-mail: |
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Abstract: | The activity of linezolid, a new oxazolidinone, was tested against 862 Gram-positive cocci isolated in Italy and compared with the activities of 12 antibiotics. Overall, MIC90s for linezolid (2–4 mg/L) indicated an in vitro activity comparable to that of vancomycin in methicillin-resistant Staphylococcus aureus (4 mg/L), S. epidermidis (2 mg/L) and methicillin-susceptible strains. Enterococcus faecalis strains were susceptible to linezolid (MIC90 2–4 mg/L), glycopeptides and β -lactams. In E. faecium , only glycopeptides (MIC90 2 mg/L) and linezolid (MIC90 2 mg/L) were active. Linezolid was the only drug active against two strains of Enterococcus showing a VanA phenotype. Owing to its antibacterial profile, linezolid represents a promising drug for the treatment of Gram-positive infections. |
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Keywords: | In vitro activity linezolid staphylococci enterococci |
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