外周乙酰胆碱对电针镇痛作用的影响

<正> 为了探讨外周乙酰胆碱(ACh)与针刺穴位引起感觉信息一级传入的关系,本文用不能通过血脑屏障的胆碱酯酶抑制剂(新斯的明)和乙酰胆碱合成阻断剂(密胆碱)及乙酰胆碱外周给药,以升高或降低外周乙酰胆碱

ACETYLCHOLINE AND THE PRIMARY INPUT OF ACUPUNCTURE SENSATION-Influence of Perpheral Acetylcholine on the Role of Electroacupuncture Analgeesia

In order to investigate the correlation between the peripheral ACh and the primary input of acupuncture sensation, in the paper the cholinesterase inhibitor-Neostigmine and the ACh synthesis blocker-Hemicholine, which are unable to pass through blood brain barrier, and ACh were used as tools to increase or decrease the level of ACh in peripheral nerve system of rats. The results indicated that: 1) The effect of electroacupuncture analgesia can be enhenced by subcutaneous injection of neostigmine which related to the dosage used. 2) The influence of electroacupuncture analgesia can be markedly inhibited by intraperitonal injection of Hemicholine. 3) This influence of suppression by Hemicholine can be reversed at once when acetylcholine in combination with neostigmine was injected. But could not reverse by neostigminealone. It suggested that the effect of electroacupuncture analgesia and the primary input of acupuncture sensation were significantly related to the level and content of ACh in periphery.