| 红藻氨酸对海马CAl区突触传递的作用 |
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| 摘 要： |
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| 关 键 词： | 红藻氨酸 海马 CAl区 兴奋性突触后电流 抑制性突触后电流 |
Effect of kainate on the synaptic transmission in hippocampal CA1 region. |
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| Authors: | Zhi-liang Liu Ru-xiang Xu Xiao-dan Jiang Zhen Yin Cheng-yi Luo Mou-xuan Du Yu-xi Zou |
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| Institution: | Institute of Neuroscience of PLA, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. zl-liu@163.net |
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| Abstract: | OBJECTIVE: To investigate the effect of activated kainate receptor on both the excitatory and inhibitory synaptic transmission in the neurons in the hippocampal CA1 region. METHOD: Blind whole-cell voltage-clamp recordings were performed on the CA1 pyramidal cells in adult rat hippocampal slices to examine and analyze the effect of bath-applied kainate (10 micromol/L) on CA1 afferent fiber-evoked excitatory postsynaptic currents (EPSCs) and inhibitory postsynaptic currents (IPSCs), respectively. RESULTS: Activation of kainate receptor significantly depressed both IPSCs (P <0.01) and EPSCs (P <0.01) in neurons in the hippocampus CA1 region. CONCLUSION: Activation of kainate receptors directly inhibit excitatory and inhibitory input in those neurons, which contributes to the development of epilepsy in the hippocampus by affecting the dynamic balance of the hippocampal neurons. |
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