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C-erbB-2在贲门癌中的扩增及其临床意义
引用本文:杨文杰,王学智,岳秀兰,白晓荃. C-erbB-2在贲门癌中的扩增及其临床意义[J]. 包头医学院学报, 2008, 24(1): 19-21
作者姓名:杨文杰  王学智  岳秀兰  白晓荃
作者单位:包头医学院生物化学与分子生物学教研室,内蒙古,包头,014010;赤峰市医院
摘    要:目的:探讨贲门癌C-erbB-2癌基因扩增情况及其临床意义。方法:应用差别PCR技术检测32例贲门癌C-erbB-2癌基因扩增。结果:贲门腺癌C-erbB-2扩增率为50%;贲门癌C-erbB-2基因扩增与组织学分化程度、浸润程度均无关(P〉0.05),与淋巴结转移有关(P〈0.05)。结论:C-erbB-2癌基因扩增与贲门癌发生有密切关系,原癌基因C-erbB-2扩增可作为贲门癌淋巴结转移的生物学标志。

关 键 词:贲门癌  C-erbB-2  差别PCR  癌基因扩增
收稿时间:2007-08-16
修稿时间:2007-08-16

Amplification of Oncogene C-erbB-2 in Gastric Cardia Adenocarcinoma and Its Clinical Significance
YANG Wenjie,WANG Xuezhi,YUE Xiulan,et al. Amplification of Oncogene C-erbB-2 in Gastric Cardia Adenocarcinoma and Its Clinical Significance[J]. Journal of Baotou Medical College, 2008, 24(1): 19-21
Authors:YANG Wenjie  WANG Xuezhi  YUE Xiulan  et al
Affiliation:YANG Wenjie,WANG Xuezhi,YUE Xiulan,et al(Department of Biochemistry,Baotou Medical College,Baotou 014010,China)
Abstract:Objective:To explore the amplication of C-erbB-2 oncogene in Gastric cardia adenocarcinoma(GCA) and its clinical significance.Methods:Oncogene C-erbB-2 amplification was examined by differential polymerase chain reaction in 32 cases of GCA.Results:16 out of 32 cases of GCA were found to have C-erbB-2 amplification.C-erbB-2 amplification in GCA was not correlated to histology differentiation and invasion degrees,but to lymph node metastasis.Conclusion: These results suggest that there is a close relationship...
Keywords:C-erbB-2
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