Acute toxicity of aristolochic acid in rodents

The acute toxic effects of aristolochic acid (AA) were tested in rats and mice of both sexes. Oral or intravenous administration in high doses was followed by death from acute renal failure within 15 days. Histologically, the predominant features were severe necrosis affecting the renal tubules, atrophy of the lymphatic organs and large areas of superficial ulceration in the forestomach, followed by hyperplasia and hyperkeratosis of the squamous epithelium. The LD₅₀ ranged from 56 to 203 mg/kg orally or 38 to 83 mg/kg intravenously, depending on species and sex.Dedicated to Dr. Rolf Madaus on the occasion of his 65th birthday.