| 系统性红斑狼疮血中IL-18的变化及临床意义 |
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| 引用本文： | 蒋莉,刘海娜,王晓非,吴春玲,张晓莉.系统性红斑狼疮血中IL-18的变化及临床意义[J].中国医科大学学报,2005,34(6):577-578. |
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| 作者姓名： | 蒋莉 刘海娜 王晓非 吴春玲 张晓莉 |
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| 作者单位： | 中国医科大学附属第一医院风湿免疫科,辽宁,沈阳,110001 |
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| 摘 要： | 目的:探讨系统性红斑狼疮(SLE)患者血中白细胞介素18(IL-18)的变化及临床意义.方法:采用双抗体夹心(ELISA)法对SLE患者及正常对照者血中IL-18进行测定.结果:活动期SLE血中IL-18明显增高,SLE伴尿常规明显异常者IL-18增高最明显,IL-18水平与尿蛋白的增加呈正相关,与SLE活动指标中抗ds-DNA呈正相关,与C3、C4变化呈负相关.结论:IL-18通过直接或间接影响某些免疫过程参与SLE的病理损伤过程.
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| 关 键 词： | 系统性红斑狼疮 白细胞介素18 狼疮肾炎 |
| 文章编号： | 0258-4646(2005)06-0577-02 |
| 收稿时间： | 2005-03-01 |
| 修稿时间： | 2005年3月1日 |
Change and clinical significance of interleukin-18 in patients with systemic lupus erythematosus |
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| JIANG Li,LIU Hai-na,WANG Xiao-fei,WU Chun-ling,ZHANG Xiao-li.Change and clinical significance of interleukin-18 in patients with systemic lupus erythematosus[J].Journal of China Medical University,2005,34(6):577-578. |
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| Authors: | JIANG Li LIU Hai-na WANG Xiao-fei WU Chun-ling ZHANG Xiao-li |
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| Institution: | Department of Rheumatology and Immunology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China |
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| Abstract: | Objective: To study the change and clinical significance of interleukin-18(IL-18) in patients with systemic lupus erythematosus(SLE).Methods: The level of IL-18 was measured in SLE patients and normal subjects by enzyme-linked immunosorbent assay.Results: The level of IL-18 in patients with active SLE was much higher than that in normal subjects.The level of IL-18 increased most obviously and was positively related to the increase of the urine protein in SLE patients with abnormal urine routine.IL-18 was positively related to anti-ds-DNA antibody but negatively related to C3 and C4.Conclusion: IL-18 participates directly or indirectly in the pathological damage of SLE by affecting immune processes. |
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| Keywords: | systemic lupus erythematosus interleukin-18 lupus nephritis |
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