IL-6与肥胖和胰岛素抵抗的关系

目的：探讨血清IL-6水平以及IL-6基因多态性与肥胖和胰岛素抵抗（IR）的关系。方法：选取肥胖2型糖尿病患者55例（肥胖组），非肥胖2型糖尿病患者49例（非肥胖组），健康对照50例（对照组），应用酶联免疫法检测血清中IL-6水平，并应用PCR-RFLP方法检测IL-6-174启动子区基因多态性。结果：肥胖组血清IL-6水平较非肥胖组及对照组明显增高．在糖尿病组中IL-6-174G等位基因携带者体质量指数（BMI）及IR均高于IL-6-174C等位基因携带者。结论：IL-6与BMI和IR有关，携带IL-6-174G等位基因者更易于发生IR。

Relation between IL-6 and Insulin Resistance in Type 2 Diabetes

Objective:To investigate the relationship between the polymorphism of interleukin-6(IL-6) and insulin resistance(IR) of type 2 diabetes.Methods:Fifty-five patients of type 2 diabetes with obesity,49 type 2 diabetes without obesity and 50 healthy people were included in the study.Enzyme-linked immunoadsorbent assay was used in IL-6 measurement.The promoter polymorphism of the IL-6(G-174C) was detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) .Data was analyzed using SPSS 10.0.Results:The level of serum IL-6 in the type 2 diabetes with obesity was higher than that of other two groups(P < 0.05 or P < 0.01) .The IL-6-174G allele was associated with higher body mass index(BMI) and insulin resistance in type 2 diabetes.Conclusion:The level of serum IL-6 was positively related to BMI and insulin resistance.The high incidence of insulin resistance may be due to increased production of IL-6 in subjects with the-174G allele.