利用SPSS估算血管外给药的药动学参数

目的 利用SPSS估算血管外给药室模型的药动学参数。方法使用SPSS的非线性回归(nonlinear regression)拟合模拟的两室模型血管外给药的药-时数据；依据95％置信区间决定是否在模型中保留滞后时间(tlag)项。结果SPSS估算的药动学参数：住确可靠；根据tlag95％置信区间决定是否在模型中保留flag项是合理的。结论SPSS适用于估算血管外给药室模型的药动学参数。

Estimating the pharmacokinetic parameters in extravascular administration by SPSS

OBJECTIVE To estimate the pharmacokinetic parameters of compartment models with extravascular administration using SPSS.METHOD Concentration-time data from the simulation of two-compartment model with the 1st order absorption and lag time( t _ lag ) were fitted using SPSS nonlinear regression. 95% confidence interval (95% CI) for t _ lag was used to determine if t _ lag item remained in the model.RESULTS The pharmacokinetic parameters obtained from SPSS were exact and reliable. It was reasonable to determine if t _ lag item remains in the model according to its 95% CI.CONCLUSION SPSS is suitable for estimating the pharmacokinetic parameters of compartment models with extravascular administration.