高血压及高血压合并糖尿病患者血浆RAS与胰岛素水平分析

目的：观察高血压及高血压合并糖尿病患者血浆RAS活性对血浆胰岛素水平的影响。结果：①按血浆胰岛素水平分组；B组（＞10＜15mIu/L)、C组（＞15＜20mIu）和D组（＞20mIu／L）及高血压合并糖尿病组患者血浆肾素活性（PRA）、血管紧张素Ⅱ（ATⅡ）水平明显高于A组（＜10mIu/L)患者。血糖／胰岛素（G／I）则是显著降低，高血压组患者中，PRA和ATⅡ浓度呈现随胰岛素水平升高而增加的趋势，但无统计学意义。②按PRA分组；将高血压患者按PRA分组三组，a组（PRA＜1．0ng/ml/h);b组（PRA＞1．0＜1．5ng/ml/h)和c组（PRA＞1．5ng/ml/h)。结果显示,b组和c的胰岛素水平明显高于a组，并且胰岛素浓度随PRA活性增加而明显升高，结论高血压患者RAS活性增加与血浆胰岛素浓度增加密切相关，RAS活性增加可能是胰岛素抵抗（IR）的原因之一。

Analysis of RAS and Level of Plasma Insulin in Patients with Hypertension and Hypertension Complicated with Diabetic Mellitus

Objective To observe the effects of renin-angiotensin system on the plasma insulin levels in patients with hypertension and hypertension complicated with diabetic mellitus.Results ① The patients were subgrouped on plasma insulin levels: Compared with subgroup A (insulin levels was ＜10 mIu/L),the plasma renin activity (PRA) and angiotensin Ⅱ(ATⅡ) were significantly increased, and the glucose/insulin ratio (G/I) were decreased significantly in subgroup B (insulin levels was＞10,＜15 mIu/L), subgroup C(＞15,＜20 mIu/L), subgroup D(＞20 mIu/L) and in the group complicated with type 2 diabetic mellitus. ② According to PRA, we subdivided the hypertensive patents into three subgroup, group a (PRA was ＜0.1 ng/ml/h); group b (＞1.0,＜1.5 ng/ml/h); group c(＞1.2 ng/ml/h). The results showed that plasma insulin levels were higher in group b and c than that in group a and rose significantly with the increase in RAS.Conclusion The increased activity of RAS is correlated with the hyperinsulinemia and may be one of the causes of insulin-resistance(IR).