餐后高血糖对成年男性心血管疾病危险因素的影响

目的研究35~55岁成年男性餐后高血糖对心血管疾病危险因素聚集性的影响。方法对在荆州市中心医院健康体检的35~55岁的无糖尿病和心血管疾病确诊病史的男性人员中,以空腹血糖(FBG)<6.1 mmol.L-1为标准,共选取543名研究对象。以早餐后2 h血糖(P2hBG)为标准分3组,Ⅰ组:P2hBG<7.8 mmol.L-1,Ⅱ组:7.8 mmol.L-1≤P2hBG<11.1 mmol.L-1,Ⅲ组:P2hBG≥11.1 mmol.L-1组。比较高血压、腰围(WL)、血脂紊乱、糖基化血红蛋白A1c(GHbA1c)、C反应蛋白(CRP)、胰岛素抵抗、空腹胰岛素(Fins)等心血管病危险因素在各组的聚集性。结果随着餐后血糖升高,Fins、WL、收缩压、舒张压、甘油三酯(TG)、胰岛素抵抗指数(HOMA-IR)、GHbA1c和CRP均升高,高密度脂蛋白胆固醇(HDL-c)下降,差别均有统计学意义(P<0.05);以P2hBG应变量,以WL、血压、CRP、TG和HOMA-IR为自变量作多元回归分析,上述自变量均与P2hBG呈线性回归关系(P<0.05)。结论35~55岁的成年男性随着餐后血糖升高,心血管危险因素聚集性增加。

Effect of postprandial hyperglycemia on the risk factors of cardiovascular disease in adult males

Objective To investigate the effect of postprandial hyperglycemia on the aggregation of cardiovascular disease risk factor at the age from 35 to 55 adult males. Methods Five hundreds and forty-three at the age from 35 to 55 adult males without history of diabetes and coronary heart disease were selected out of staff who did physical examination in Jingzhou center hospital, according to the standard of fasting blood glucose （FBG） 〈 6.1 mmol · L^- 1, then divided into three groups depended on postprandial blood glucose ： in group Ⅰ ： P2hBG 〈 7.8 mmol · L ^- 1, in group Ⅱ ： 7.8 mmol · L^ - 1 ≤ P2hBG 〈 11.1 mmol · L^- 1, in group Ⅲ ：P2hBG ≥ 11. 1 mmol · L^-1. The risk factors of cardiovascular were compared in each groups, such as high blood pressure, waistline （ WL）. serum lipid disorders, Glvcosvlated hemoglobin Al c （ GHbAl c ）, C-reactive protein （ CRP ）, insulin resistance and high fasting insulin. Results With the increasing of postprandial blood glucose, Fins, WL, systolic blood pressure, diastolic blood pressure, triglyeride （ TG）, HOMA-IR, GHbAl c and CRP were increased, while high density lipoprotein cholesterol （HDL-c） decreased,The differences between each group were statistical significance （P 〈 0. 05 ）. By multiple logistic regression analyses,it showed that WL, blood pressure, CRP, TG, and HOMA-IR were the linear regression related to P2hBG （ P 〈 0.05 ）. Conclusion With the increasing of postprandial hyperglycemia, the aggregation of the risk factors of cardiovascular increase at the age from 35 to 55 adult males.