| Seroreactivity against Saccharomyces cerevisiae in patients with Crohn＇s disease and celiac disease |
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| 引用本文： | Barta Z,Csíp? I,Szabó GG,Szegedi G.Seroreactivity against Saccharomyces cerevisiae in patients with Crohn＇s disease and celiac disease[J].世界胃肠病学杂志(英文版),2003,9(10):2308-2312. |
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| 作者姓名： | Barta Z Csípõ I Szabó GG Szegedi G |
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| 摘 要： | AIM: To explore whether there was anti-Saccharomyces cerevisiae antibodies (ASCA) positivity in our patients with biopsy-confirmed celiac disease. METHODS: A cohort of patients with inflammatory bowel diseases (42 patients with Crohn‘‘s disease and 10 patients with ulcerative colitis) and gluten sensitive enteropathy (16 patients) from Debrecen, Hungary were enrolled in the study.The diagnosis was made using the formally accepted criteria.Perinuclear antineutrophil cytoplasmic antibodies (pANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA),antiendomysium antibodies (EMA), antigliadin antibodies(AGA) and anti human tissue transglutaminase antibodies(tTGA) were investigated.RESULTS: The results showed that ASCA positivity occurred not only in Crohn‘‘s disease but also in Celiac disease and in these cases both the IgG and IgA type antibodies were proved.CONCLUSION: It is conceivable that ASCA positivity correlates with the (auto-) immune inflammation of small intestines and it is a specific marker of Crohn‘‘s disease.
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| 关 键 词： | 克隆病 腹部疾病 酵母菌 pANCA 抗体 炎症 |
| 收稿时间： | 2003 Mar 12 |
Seroreactivity against Saccharomyces cerevisiae in patients with Crohn's disease and celiac disease |
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| Barta Zsolt,Csíp? István,Szabó Gábor G,Szegedi Gyula.Seroreactivity against Saccharomyces cerevisiae in patients with Crohn's disease and celiac disease[J].World Journal of Gastroenterology,2003,9(10):2308-2312. |
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| Authors: | Barta Zsolt Csípõ István Szabó Gábor G Szegedi Gyula |
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| Institution: | 3rd Dept. of Medicine, University of Debrecen, Moricz Zs. Krt.22. 4004 Debrecen, Hungary. barta@iiibel.dote.hu |
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| Abstract: | AIM: To explore whether there was anti-Saccharomyces cerevisiae antibodies (ASCA) positivity in our patients with biopsy-confirmed celiac disease. METHODS: A cohort of patients with inflammatory bowel diseases (42 patients with Crohn's disease and 10 patients with ulcerative colitis) and gluten sensitive enteropathy (16 patients) from Debrecen, Hungary were enrolled in the study. The diagnosis was made using the formally accepted criteria. Perinuclear antineutrophil cytoplasmic antibodies (pANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA), antiendomysium antibodies (EMA), antigliadin antibodies (AGA) and anti human tissue transglutaminase antibodies (tTGA) were investigated. RESULTS: The results showed that ASCA positivity occurred not only in Crohn's disease but also in Celiac disease and in these cases both the IgG and IgA type antibodies were proved. CONCLUSION: It is conceivable that ASCA positivity correlates with the (auto-) immune inflammation of small intestines and it is a specific marker of Crohn's disease. |
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