Pregnancy: Prospective follow-up study of 55 children born after subzonal insemination and intracytoplasmic sperm injection

In 163 couples referred for assisted fertilization, pregnancywas established by subzonal insemination (SUZI), intracytoplasmicsperm injection (ICSI) or a combination of both techniques.These couples agreed to participate in a prospective study thatincluded a prenatal diagnosis and clinical follow-up of thechildren. No cytogenetic aberrations were observed in 43 childrentested. In 23 pregnancies occurring after SUZI, 15 women gavebirth to 21 children. After replacement of combined SUZI andICSI embryos, 10 pregnancies resulted in 8 deliveries with 10children. Transfer of ICSI embryos led to 130 pregnancies endingin 20 deliveries with 24 children, with many others still ongoingsuccessfully. In total, 55 children have been examined: 29 boysand 26 girls. One child from a singleton pregnancy presentedmultiple congenital malformations; one twin child presenteda quadriparesis. In this observational study on a limited numberof children, the incidence of major malformations was not differentfrom the incidence in the general population.