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Effect of a peptide extract of fetal brain tissue on the intracellular pH of mouse peritoneal phagocytes
Authors:V B Turovetskii  N B Porodina  A N Erin  E M Molnar  G T Sukhikh
Institution:(1) International Institute of Biological Medicine, Moscow
Abstract:The intracellular pH (pHi) of mouse peritoneal neutrophils, initially 0.2 U, drops after a 15-min incubation of these cells with a peptide extract of fetal brain tissue. Treatment with the preparation leads to appreciable changes in the distribution of neutrophils by the examined parameter. For macrophages, the acidifying effect of the agent and its effect on the pattern of cell distribution in terms of pH values are far less expressed. The effects of the agent in dilutions 1∶102 and 1∶104 on the mean pHi are virtually the same. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N o 12, pp. 626–630, December, 1995 Presented by V. I. Kulakov, Member of the Russian Academy of Medical Sciences
Keywords:peptides                      neutrophils                      macrophages                      intracellular pH
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