microRNAs参与toll样受体介导内毒素耐受的研究进展

Toll样受体（Toll-Like Receptor，TLR）配体脂多糖（Lipopolysaccharide, LPS），能诱导机体产生免疫耐受（或交叉耐受），其信号途径受到多种机制的精密调控，在天然免疫中扮演重要角色。microRNAs是Toll样受体通路中常见信号分子IL-1受体相关激酶（IRAK1、IRAK2）和肿瘤坏死相关因子6（TRAF6）的关键靶向元件，参与了免疫耐受（或交叉耐受）的建立及维持。本综述主要讨论了Toll样受体介导耐受形成的机制，并阐述其配体诱导的microRNAs的调节功能，看是否影响Toll 样受体信号途径的激活以及内毒素耐受的建立、维持，对抗炎症疾病治疗的具有重要指导意义。

The research progress of microRNAs involved toll-like receptors mediated endotoxin tolerance

Tolerance or cross resistance induced by toll-like receptor ligands lipopolysaccharide (LPS) plays an important role in natural immune regulation. As the main mechanism of tolerance, toll-like receptors pathway is regulated by a variety of precision adjustment mechanism. MicroRNAs, such as miR-146a is a key target element of common signaling molecules such as IL-1 receptor related kinase (IRAK1, IRAK2) and tumor necrosis factor 6 (TRAF6), participating in the establishment and maintenance of tolerance. The review mainly discussed the toll-like receptor mediated tolerance forming mechanism induced by microRNAs. The microRNAs may play an important role in the activation of TLR pathway, tolerance establishment and the development of anti-inflammatory treatment.