HLA-DP基因多态性与肺癌遗传易感性研究

目的 探讨人类白细胞抗原（Human Leukocyte Antigens，HLA）DP基因多态性与中国汉族人群肺癌遗传易感性的关联。方法 应用TaqMan探针方法检测401例肺癌患者和843例对照者 rs3077和rs9277535位点基因型，比较不同基因型与肺癌患病风险的关系。结果 采用多因素Logistic回归分析，结果显示rs3077和rs9277535位点突变基因型AA显著增加肺癌的发病风险（调整OR = 1.69，95%CI = 1.16～2.51；调整OR = 1.58，95%CI = 1.10～2.25）；单倍型分析显示，与GG单倍型相比，携带AA单倍型的个体可增加肺癌发病风险（调整OR = 1.41，95%CI = 1.61～1.71）；与携带rs3077 GG+GA and rs9377357 GG基因型的个体相比，携带1～4个危险等位基因的个体发生肺癌的风险显著（P趋势 ＜0.01）。结论 HLA基因多态性与中国汉族人群肺癌的发病风险存在关联。

Correlation between HLA-DP polymorphisms and susceptibility to lung cancer

Objective This work was to explore the association between HLA-DP polymorphisms and susceptibility to lung cancer. Methods Two variants of rs3077 and rs9277535 were genotyped among 401 lung cancer cases and 843 controls by using TaqMan technology. Results Logistic regression analyses showed that the mutant genotype AA of rs3077 and rs9277535 significantly increased the risk of lung cancer (adjusted OR = 1.69, 95% CI:1.16-2.51; adjusted OR = 1.58, 95%CI:1.10-2.25). Haplotype analysis also showed that haplotype AA significantly increased the risk of lung cancer in comparison to the GG haplotype (adjusted OR=1.41, 95%CI=1.61-1.71). When combining the effects of HLA-DP rs3077 and rs9277535，subjects carrying one or more variant alleles increased risk of lung cancer (Ptrend < 0.01)，in comparison to those carrying no variant allele. Conclusion HLA-DP polymorphisms might play an vital role in the susceptibility of lung cancer among Chinese population.