连云港市赣榆区1～10岁健康儿童流行性脑脊髓膜炎A、C群、百日咳、白喉、破伤风抗体水平的监测

目的 了解江苏省连云港市赣榆区1～10岁健康儿童流行性脑脊髓膜炎A、C群（分别简称A群流脑和C群流脑）、百日咳、白喉、破伤风特异性抗体水平，从而为免疫规划工作提供参考依据。方法 通过儿童计划免疫管理系统，从本地25个接种点接种数据库中随机抽取1～10岁全程免疫健康儿童，采集末梢血样18 747份，采用酶联免疫吸附试验法检测上述5 种传染病特异性IgG抗体水平，并对结果进行统计学分析。结果 调查的18 747份末梢血样中，A群流脑、C群流脑、百日咳、白喉、破伤风IgG 抗体阳性率分别为97.9%、98.0 %、 99.1%、 98.5%、99.0%，各个年龄组的5种抗体阳性率均在94.9%以上。城镇儿童和农村儿童间5种抗体阳性率差异均有统计学意义，城镇儿童5种抗体阳性率均低于农村儿童。 结论 赣榆区1～10岁儿童上述5类传染病特异性抗体均维持在较高水平，城镇儿童5种抗体阳性率均低于农村儿童，应加强流动人口的免疫规划疫苗接种工作。

The serological surveillance of epidemic cerebrospinal meningitis groups A and C,pertussis, diphtheria,and tetanus among 1-10 years old children in Ganyu district Lianyungang city

Objective The aim of this study was to investigate epidemic cerebrospinal meningitis groups A and C, pertussis, diphtheria, and tetanus specific antibody levels among 1-10 years old healthy children in Ganyu district Lianyungang city, in order to provide references for local planned immunization program. Methods A total of 18,747 healthy children with the age from 1 to 10 years old, who were given infectious diseases vaccines, were randomly picked from local immune management database, and their finger-tip blood samples were taken. The sera were used to check antibody titers against epidemic cerebrospinal meningitis groups A and C, pertussis, diphtheria, and tetanus, respectively, by using commercial enzyme-linked immunosorbent assay (ELISA) kits, and the result was statistically analyzed. Results For the whole samples detected, the sera positivity for epidemic cerebrospinal meningitis group A and C, pertussis, diphtheria, and tetanus were 97.9%, 98.0%, 99.1%, 98.5% and 99.0%, respectively, and the antibody prevalence against these five infectious diseases maintained above 94.9% in all age-groups. There was significant difference in these five diseases antibody positivity between the children lived in city and that in rural area, with the children live in city being lower. Conclusion The antibody titers against the five infectious diseases described above maintained a higher level, while the sera positivity for the children live in city was lower than that in rural area. More efforts should be devoted to strength immunization, especially in the floating population.