慢性乙型肝炎患者红细胞分布宽度的变化及其与FibroTouch检测结果的相关性

目的 探讨慢性乙型肝炎(Chronic Hepatitis B,CHB)患者外周血红细胞分布宽度(RDW)的变化,并分析其与肝脏瞬时弹性测定仪FibroTouch检测结果的相关性。方法 选取CHB患者104例,健康对照者(Healthy Control,HC)123例,采用Sysmex-XN1000全自动血细胞分析仪检测外周血RDW值,采用FibroTouch检测CHB患者的肝脏硬度值和脂肪衰减参数。结果 CHB组和HC组的RDW值分别为13.79±1.82%和12.95±0.83%,差异有统计学意义( P<0.05)。Spearman相关分析显示,CHB患者RDW与其肝脏硬度值正相关( rs=0.22, P=0.02);与脂肪衰减参数不相关( rs=0.03, P=0.74)。ROC曲线分析显示,RDW预测CHB的曲线下面积(AUC)为0.67;RDW预测肝硬化(肝脏硬度值≥17.5 kPa)的AUC为0.66。结论 CHB患者RDW显著增高,并与肝脏硬度正相关。

Change of red blood cell width distribution and its correlation with the result of FibroTouch test among patients with chronic hepatitis B

Objective To investigate the changes of red blood cell width distribution (RDW) and its association with the results of FibroTouch test among patients with chronic hepatitis B (CHB). Methods 104 patients with CHB were selected as test group as well as 123 healthy cases as Healthy Controls (HC) group in this study. The value of RDW was tested by using Sysmex-XN1000 analyzer. Liver stiffness and fat attenuation parameters in CHB patients were examined with FibroTouch. Results The RDW values in patients with CHB were significantly more than those in HC group (13.79±1.82% vs 12.95±0.83%,P<0.05). And spearman correlation analysis showed that RDW was positively associated with liver stiffness (rs=0.22,P=0.02). However,the correlations between RDW and fat attenuation parameters were not observed (rs=0.03,P=0.74). ROC analysis revealed that the AUC of RDW for predicting CHB was 0.67,whereas the AUC of RDW for predicting patients with Liver cirrhosis was 0.66. Conclusion The RDW is significantly increased and associated with the degree of liver stiffness in patients with CHB.