尼可地尔治疗心脏X综合征的效果

目的 观察尼可地尔治疗心脏X综合征(CSX)的效果。方法 选择2013年1月12月在本科确诊的CSX的患者45例,随机分为试药组(n=23)及对照组(n=22)。两组患者均给予常规药物治疗,试药组在此基础上给予尼可地尔5 mg,每日3次口服,随访3个月,观察患者胸痛改善情况,复查平板运动试验。结果 对照组治疗后比治疗前劳累型心绞痛发作次数降低〔(29.8±5.5)次/月vs.(20.4±4.5)次/月,P<0.05〕,试药组治疗后比治疗前降低〔(31.7±3.4)次/月vs.(19.5±5.1)次/月,P<0.05〕。两组间比较试药组降低更加显著。两组的运动持续总时间、ST段最大压低幅度、运动试验中发作心绞痛人数均有改善,但试药组有更好的作用。结论 尼可地尔在心脏CSX患者治疗中能够在基本治疗基础上进一步改善心绞痛症状。

Effect of nicorandil on cardiac syndrome X

AIM To observe the clinical effect of nicorandil on patients with cardiac syndrome X and to analyze the treatment results. METHODS Forty-five patients diagnosed with cardiac syndrome X between January 2013 and December 2013 in our hospital were enrolled and randomly divided into nicorandil group( n = 23) and control group( n = 22). Patients in the two groups were given routine drug treatment and,in addition,nicorandil 5 mg tid orally per day was given in nicorandil group. After a 3-month follow-up,chest pain was examined and treadmill exercise test was conducted. RESULTS Angina pectoris was reduced in both control group [( 29. 8 ± 5. 5) Times / month vs.( 20. 4 ± 4. 5) Times / month,P < 0. 05] and nicorandil group [( 31. 7 ± 3. 4) Times / month vs.( 19. 5 ± 5. 1) Times / month,P < 0. 05]with better results in nicorandil group. Total duration of exercise,maximal ST segment depression,and occurrence of angina in exercise test were improved in both groups,with better results in nicorandil group. CONCLUSION: Based on the basic treatment,nicorandil can further improve the symptoms of angina pectoris in patients with cardiac syndrome X.