不同年龄段高血压病患者二尖瓣血流E/A比值与左心房及左心室重构的相关性

目的 分析不同年龄段高血压病患者二尖瓣血流E/A比值与左心房及左心室重构的相关性。方法 高血压病患者1 082（男549，女533）例，根据E/A>1和E/A<1分为两组，又将两组分别按年龄分为青年组、中年组、老年组，测量左心房内径指数（LADi）、左心室质量指数（LVMI）、收缩压（SBP）、舒张压（DBP）及脉压。结果 ①E/A>1组和E/A<1组 LADi随着年龄的增大而增大。E/A>1组LVMI随着年龄的增大而增大，E/A<1组LVMI随着年龄的增大而降低。②青年组中E/A比值与LVMI呈负相关（r=-0.377），老年组中E/A比值与LADi呈正相关（r=0.243）。结论 伴随年龄的增大E/A比值的改变在青年组与心室重构密切相关，在老年组与心房重构密切相关。

Correlation of mitral E/A ratio and left atrium and left ventricular remodeling in patients of different ages with essential hypertension

AIM To analyze the significance of mitral E/A ratio in evaluation of left atrial and left ventricular remodeling in patients of different ages with essential hypertension. METHODS One thousand and eighty-two patients with hypertension (549 males, 533 females) were divided into two groups according to E/A>1 or E/A<1, and the two groups were, respectively, subdivided into young-aged group, middle-aged group and elderly group. Left atrium diameter index (LADi), left ventricular mass index (LVMI), systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure were measured. RESULTS LADi increased with increasing age. In E/A>1 group, LVMI and pulse pressure increased with increasing age, whereas SBP and DBP decreased with increasing age. In E/A<1 group, pulse pressure increased with increasing age, but SBP, DBP and LVMI decreased with increasing age (P<0.05). In the young-age group, E/A ratio, LVMI, SBP and DBP were negatively correlated (r=-0.377, -0.353, -0.226, P<0.05). In the middle-aged group, E/A ratio, SBP and DBP were negatively correlated (r=-0.269, -0.350, P<0.05). In the elderly group, E/A ratio was positively correlated with LADi (r=0.243, P<0.05). CONCLUSION With increasing age, the change of E/A ratio is closely correlated with ventricular remodeling in young and middle-aged patients, and the change of E/A ratio is closely correlated with atrium remodeling in elderly patients.