中国人群卵巢早衰相关因素的Meta分析

目的 探讨中国女性卵巢早衰(POF)发病的危险因素和保护因素,为其病因预防提供科学依据。方法 应用Meta分析方法对17篇有关中国人群POF相关因素的病例对照研究文献进行综合分析,效应指标选用OR值和95%CI,采用Stata12.0进行异质性检验、敏感性检验和发表偏倚的评估。结果 Meta分析结果:POF的危险因素有腮腺炎病史(OR=8.79)、盆腔手术史(OR=5.23)、接触有毒物质(OR=5.05)、吸烟(OR=4.87)、人流次数(OR=3.97)、A型性格行为(OR=3.96)、家族史(OR=3.96)、口服避孕药(OR=3.96)、染发(OR=3.78)、减肥史(OR=3.58)、睡眠质量差(OR=3.32)、离异或丧偶(OR=3.08)、盆腹腔X线照射(OR=2.93)、饮酒(OR=2.59)、盆腔炎史(OR=2.58),保护因素有心情愉悦(OR=0.16)、经常食用蔬菜(OR=0.31)和参加体育锻炼(OR=0.36)。其中接触有毒物质、吸烟、睡眠质量差和食用豆制品可能存在发表偏倚。结论 POF的预防应从注意合理饮食、保持心情愉悦、避免接触有毒有害物质、炎性疾病的早期治疗以及养成良好的生活习惯等方面提供积极有效的措施。

Related factors on premature ovarian failure among Chinese people: a meta- analysis

Objective To explore the main risk factors and protective factors related to the incidence of premature ovarian failure (POF) among Chinese people,and to provide basis for the POF prevention. Methods A total of 17 published literature about case-control studies on related factors of POF were collected and analyzed synthetically by meta-analysis.Stata 12.0 software was adopted in the meta-analysis,and odds ratio (OR) and 95% confidence interval were calculated to conduct the heterogeneity test,sensitivity test and published bias for POF. Results The results showed that the risk factors of POF included mumps history (OR=8.79),pelvic surgery history (OR=5.23),exposure to toxic substances (OR=5.05),smoking (OR=4.87),the number of artificial abortion (OR=3.97),type A behavior (OR=3.96),family history (OR=3.96),oral contraceptives (OR=3.96),hair dye (OR=3.78),history of weight loss (OR=3.58),poor sleep (OR=3.32),divorce or widow (OR=3.08),abdominal and pelvic X-ray radiation (OR=2.93),drinking (OR=2.59),and pelvic inflammatory history (OR=2.58).Meanwhile,the protective factors included good mood (OR=0.16),regular consumption of vegetables (OR=0.31) and often exercise (OR=0.36). Conclusion In order to prevent and control POF,positive and effective measures should be taken in the following aspects: Paying attention to diet,keeping good mood,avoiding toxic substances exposure,early treatment of inflammatory diseases and developing good living habits.