老年高血压病患者血压昼夜节律与MCP-1、sICAM-1和Hcy的相关性

目的 分析老年高血压病患者血压昼夜节律与单核细胞趋化蛋白（MCP）-1、细胞间黏附分子(sICAM)-1和同型半胱氨酸(Hcy)的相关性。方法 选入我院住院确诊的老年原发性高血压患者172例，所有病例均进行24 h无创动态血压监测，根据患者血压昼夜节律变化，将患者分为杓型组（n=55）、非杓型组(n=71)和反杓型组(n=46)。检测患者的血清MCP-1、sICAM-1和Hcy的含量。结果 杓型组、非杓型组和反杓型组MCP-1、sICAM-1和Hcy水平依次升高〔分别为(27±13)ng/L、(32±14)ng/L和(37±12)ng/L;(2433±745)ng/L、(2726±573)ng/L和(2862±514)ng/L；(16±8)mmol/L、(19.15±8.4)mmol/L和(22±10)mmol/L，均P<0.05〕；多元逐步线性回归显示MCP-1、sICAM-1和Hcy为患者血压节律改变的影响因素，偏回归系数分别为-0.001、-2.1×10-5、-0.002。结论 MCP-1、sICAM-1、Hcy为老年高血压病患者血压昼夜节律改变的相关因素。

Relationship between blood pressure circadian rhythm and monocyte chemattractant-1, intercellular adhesion molecule-1 and homocysteine in elderly hypertensive patients

AIM To explore the relationship between blood pressure circadian rhythm and monocyte chemoattractant-1, intercellular adhesion molecule-1 and homocysteine in elderly hypertensive patients. METHODSA total of 172 patients with elderly primary hypertension undergoing 24-h ambulatory blood pressure monitoring were included in this study and divided into three groups: dipper group (n=55), non-dipper group (n=71) and reverse dipper group (n=46). Monocyte chemattractant-1 (MCP-1), intercellular adhesion molecule-1 (sICAM-1) and homocysteine (HCY) were detected in all patients. RESULTSThe levels of MCP-1, sICAM-1 and HCY increased, respectively, in all three groups ［(27±13) ng/L, (32±14) ng/L and (37±12) ng/L; (2433±745) ng/L, (2726±573) ng/L and (2862±514) ng/L; (16±8) mmol/L, (19.15±8.4) mmol/L and (22±10) mmol/L; all P<0.05］. Stepwise multivariate linear regression showed that MCP-1, HCY and sICAM-1 may be the influencing factors of blood pressure circadian rhythm (partial regression coefficient (B): -0.001, -2.1×10-5 and -0.002, respectively). CONCLUSIONMCP-1, sICAM-1 and HCY may be the influencing factors of blood pressure circadian rhythm in elderly hypertensive patients.