HFE基因多态性与丙型肝炎病程进展的相关性研究

目的 探讨遗传性血色素沉着病蛋白(Hemochromatosis,HFE)基因多态性与中国汉族人群丙型肝炎病程进展的关联。方法 应用TaqMan探针方法检测262例无症状携带者和253例进展性肝炎组rs2071303和rs9366637位点基因型,比较不同基因型与与丙型肝炎病程进展相关性。结果 采用多因素logistic回归分析,结果显示rs2071303位点突变基因型AA可以增加丙型肝炎进一步进展的风险(调整 OR=1.78,95% CI:1.08-2.92);单倍型分析显示,与GC单倍型相比,携带AC单倍型的个体可增加丙型肝炎进一步进展的风险;(调整 OR=2.86,95% CI:1.58-5.58)。结论 HFE基因多态性与中国汉族人群丙型肝炎病程进展存在关联。

Relationship between HFE polymorphisms and progression of hepatitis C

Objective To explore the association between HFE polymorphisms and progression of hepatitis C. Methods Two variants of rs2071303 and rs9366637 were genotyped among 262 asymptotic HCV carriers and 253 subjects with HCV-related diseases by using TaqMan technology. Results Logistic regression analyses showed that the mutant genotype AA of rs2071303 significantly increased the risk of progression of hepatitis C (adjusted OR=1.78,95%CI:1.08-2.92)Haplotype analysis also showed that haplotype AC significantly increased the risk of progression of hepatitis C compared with the GC haplotype (adjusted OR=2.86,95%CI=1.58-5.58). Conclusion HFE polymorphisms might play a vital role in the progression of hepatitis C among the Chinese population.