黄芪注射液对大鼠急性肝损伤保护作用的量效关系

目的观察不同剂量黄芪注射液对硫代乙酰胺(TAA)所致大鼠急性肝损伤的影响。方法将50只雄性大鼠随机分为5组,给药后测定血清中谷丙转氨酶(ALT)和谷草转氨酶(AST)活性,取肝组织作病理学检查。结果不同剂量组的黄芪注射液均可明显降低TAA所致大鼠血清中ALT和AST活性升高,并呈明显的量效关系。黄芪注射液组肝组织变性、坏死的程度与对照组比较明显减轻(P<0.001)。结论黄芪注射液对TAA所致大鼠急性肝损伤具有明显的保护作用。

Dose-effect relationship of protection of Astragalus injection for acute liver injury in rats

Objective To observe the effects of Astragalus injection of different doses on TAA-induced acute liver injury in rats.Methods Fifty male rats were randomly divided into 5 groups and Astragalus injection was used for protecting against liver injury,and at the end of the experiment,the levels of serum ALT and AST were detected and hepatic tissues were performed with pathological analysis.Results Astragalus injection of different doses could obviously decrease the activity of serum aspartate aminotransferase(AST) and alanine transaminase(ALT) in rats induced by thioacetamide(TAA),which demonstrated obvious dose-effect relationship.Degree of degeneration and necrosis of hepatic tissues of treatment group was obviously lessened compared with control group(P<0.001).Conclusion Astragalus injection plays a very important role in protection of acute liver injury induced by TAA in rats.