人Y染色体类热休克蛋白因子编码特征和男性生精障碍

精子生成障碍是男性不育的主要原因之一，而无精症和少精症在男性不育症患者中，90％是由于生精功能障碍引起，其中特发性生精障碍占60％。近年来通过人类基因组计划的实施，发现不少Y染色体上诱发不育症的候选基因，包括类热休克蛋白因子HSFY、LW-1和mHSFYL。本文通过HSFY、LW-1和mHSFYL的编码特征，阐述它们在精子生成过程中的作用和诱发生精障碍、导致无精症和少精症的遗传学机理。

Encoded characteristics of heat shock-Like proteins on human Y chromosome and male spermatogenic obstacles

spermatogenesis obstacle is one of the major causes of male infertility,and 90 percent of azoospermia in male infertility patients,is due to spermatogenic dysfunction,idiopathic spermatogenic obstacles of them was 60%.In recent years through the human genome project implementation,many of the candidate gene-induced infertility on the Y chromosome were found,including the type of heat shock-like protein factor HSFY,LW-1 and mHSFYL.BY BHSFY,LW-1 and mHSFYL coding features,this paper described genetic mechanism of them in the process of sperm formation and the role of spermatogenic obstacles induced,leading to azoospermia and azoospermia.