非高密度脂蛋白胆固醇在老年高血压及糖尿病人群中的临床意义

目的探讨非高密度脂蛋白胆固醇(non-HDL-C)对患有高血压、糖尿病的老年人群发生心血管事件风险的临床预测价值。方法入选2003年12月至2009年5月老年住院患者(≥60岁)326例,根据临床主要诊断分为高血压组(104例)、糖尿病组(58例)、高血压合并糖尿病组(109例)以及健康对照组(55名)。空腹测定血清TC、TG、HDL-C、LDL-C,non-HDL-C应用公式(TC-HDL-C)计算。对所有入选者出院后完成至少1年的临床随访。结果高血压组、糖尿病组、高血压合并糖尿病组患者的TC、TG、LDL-C和non-HDL-C水平均高于健康对照组,HDL-C水平则相反,而non-HDL-C在高血压合并糖尿病组与健康对照组间差异有统计学意义[(3.44±1.02)mmol/L比(2.88±0.84)mmol/L,P<0.05]。随访结果显示,前3组发生心血管事件的患者明显多于健康对照组,特别是non-HDL-C>2.59mmol/L的患者,除糖尿病组外,差异均有统计学意义(均为P<0.05)。结论 Non-HDL-C是心血管疾病的死亡预测因子,对患有高血压、糖尿病的老年人群心脑血管病的发生也有着较好的临床预测价值。

Clinical significance of non-high density lipoprotein cholesterol in elderly patients with diabetes and hypertension

Objective To investigate the clinical significance of non high density lipoprotein(non-HDL-C) as a marker for cardiovascular risk in elderly population with diabetes and hypertension.Methods We enrolled 326 elderly patients during December 2003 to May 2009.The patients were divided into four groups according to the first clinical diagnosis in hospital:the hypertension group(n = 104 ),the diabetes group(n = 58 ),the hypertension with type 2 diabetes group(n = 109) and the control group(n =55).Serum triglycer...