胃蛋白酶原在胃癌诊断中的价值探讨

目的通过测定血清胃蛋白酶原（pepsinogen，PG）PGⅠ、PGⅡ的水平及其比值变化，探索血清PG在胃癌诊断中的应用价值。方法采用ELISA方法，测定胃癌患者（23例）、胃良性病变患者（69例）和健康对照人群（25名）的血清PGⅠ、PGⅡ的水平。结果胃癌患者组血清PGⅠ水平及PGⅠ／PGⅡ比值低于胃良性病变组及健康对照组，差异有统计学意义（户〈0．05）；胃癌患者组PGII水平与健康对照组及胃良性病变组比较，差异无统计学义（P〉0．05）；Logistic回归分析显示：PGⅠ对胃癌分类能力为80．6％，PGⅠ／PGⅡ比值对胃癌分类能力为73．9％；ROC曲线显示：PGⅠ、PGⅠ／PGⅡ比值的曲线下面积（AUC）分别为0．82、0．77。结论血清PGⅠ的含量及PGⅠ／PGⅡ的比值改变，可以作为胃癌诊断的重要指标。

Evaluation of the Value of Serum Pepsinogen in the Diagnosis of Gastric Cancer

Objective To evaluate value of the levels of gastric cancer by detecting serum levels of pepsinogen of PG Ⅰ ,PG Ⅱ ,and PG Ⅰ/PG Ⅱ ratio in the diagnosis Ⅰ （PG Ⅰ ） and pepsinogenⅠ/（PG Ⅱ ） in gastric cancer patients. Methods The serum levels ofPG Ⅰ ,PG Ⅱ of the normal control group（n=25）,gastric cancer group（n=23） and the benign group（n=69） were detected by ELISA. Results The serum PG Ⅰ ,PG Ⅰ/PG Ⅱ levels of gastric cancer group were lower than the normal control group and the benign group（P 〈 0.05）;The PG II levels of gastric cancer group were not significantly different from the benign group and the normal control group（P 〉 0.05）;The logistic regression showed that the classification abilities of PG I and PG Ⅰ/PG Ⅱ to gastric cancer were 80.6% and 73.9% respectively.The ROC curve showed that the AUC（area under curve） of PG I and PG Ⅰ/PG Ⅱ were 0.82 and 0.77 respectively.Conclusion The changes of serum levels of PGⅠ and PG Ⅰ/PG Ⅱ ratio are important indexes in the diagnosis of gastric cancer.