| 芳香稠环取代酰氯的合成 |
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| 引用本文： | 胡文祥,恽榴红,张连锋,.芳香稠环取代酰氯的合成[J].药学学报,1997,32(9):699-703. |
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| 作者姓名： | 胡文祥 恽榴红 张连锋 |
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| 作者单位： | 国防科工委军事医药研究发展中心，军事医学科学院毒物药物研究所 |
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| 摘 要： | 芳香稠环取代酰氯的合成胡文祥恽榴红张连锋（国防科工委军事医药研究发展中心，北京１００１０１；军事医学科学院毒物药物研究所，北京１００８５０）许多高效药物和激素用量甚少，分布全身代谢后血药浓度更低，并且它们又往往不含强烈的发色基团，因此在药代...
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| 关 键 词： | 9-蒽丙烯酰氯 1-芘丙烯酰氯 荧光探针 |
| 收稿时间： | 1996-06-20 |
SYNTHESIS OF CARBONYL CHLORIDES SUBSTITUTED WITH AROMATIC DENSE RING |
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| WX Hu,LH Yun and LF Zhang.SYNTHESIS OF CARBONYL CHLORIDES SUBSTITUTED WITH AROMATIC DENSE RING[J].Acta Pharmaceutica Sinica,1997,32(9):699-703. |
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| Authors: | WX Hu LH Yun and LF Zhang |
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| Institution: | Center of Research and Development of Medicine and Pharmaceuticals, Commission of Science & Technology and Industry for National Defence, Beijing 10010.. |
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| Abstract: | Carbonyl chlorides substituted with aromatic dense-ring are chemically active and their fluorescent quantum yields are usually high and they may be used as fluorescent probes for detection of many compounds. Studies on their synthesis and structure activity relationship are very important in the micro-or supermicro-detection of drugs and toxicants containing hydroxy groups. Therefore, the probes may find wide application in the chemical engineering and pharmaceutical industry. Three new fluorescent probes: Beta-(9-anthracene) acrylonyl chloride, Beta-(9-anthracene) propionyl chloride and Beta-( 1-pyrene ) acrylonyl chloride were synthesized by the reaction between the corresponding acid and thionyl chloride. 1-Prenecarboxaldehyde synthesized by using pyrene and N-formyl-N-methylaniline with phosphorus oxychloride as catalyst, was allowed to react with malonic acid to produce Beta-(1-pyrene) acrylic acid for the last-mentioned acid chloride. |
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| Keywords: | β-(1-Pyrene) acrylonyl chloride Fluorescent probes β-(9-Anthracene) acrylonyl chloride |
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