| 多重置换扩增在植入前遗传学诊断中的应用及展望 |
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| 引用本文： | 张印峰,罗海宁,黎小佩,张云山.多重置换扩增在植入前遗传学诊断中的应用及展望[J].中华医学遗传学杂志,2012,29(4):431-434. |
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| 作者姓名： | 张印峰 罗海宁 黎小佩 张云山 |
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| 作者单位： | 1. 300052, 天津市中心妇产科医院生殖中心
2. 天津医科大学 |
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| 摘 要： | 多重置换扩增是一种新兴的全基因组扩增技术,能对单个细胞进行全基因扩增,产生大量的优质DNA,具有高扩增效率和高保真性等特点.多重置换扩增联合常规PCR已被成功用于植入前遗传学诊断,进一步扩展了后者的应用范围.
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| 关 键 词： | 多重置换扩增 植入前遗传学诊断 全基因组扩增 |
Applications and prospect of multiple displacement amplification in preimplantation genetic diagnosis |
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| ZHANG Yin-feng
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LUO Hai-ning
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LI Xiao-pei
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ZHANG Yun-shan.Applications and prospect of multiple displacement amplification in preimplantation genetic diagnosis[J].Chinese Journal of Medical Genetics,2012,29(4):431-434. |
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| Authors: | ZHANG Yin-feng LUO Hai-ning LI Xiao-pei ZHANG Yun-shan |
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| Institution: | Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, People's Republic of China. |
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| Abstract: | Multiple displacement amplification (MDA) is a new technology for whole genome amplification (WGA), which can generate large amount of high-quality DNA and features high amplification efficiency and fidelity. MDA combined with conventional PCR techniques has been successfully applied for preimplantation genetic diagnosis, which has broaden latter's clinical applications. |
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| Keywords: | Multiple displacement amplification Preimplantation genetic diagnosis Whole genome amplification |
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