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| 藻酸双酯钠对肺炎病儿细胞黏附分子表达的影响 | |
| 引用本文： | 刘成玉,张银亭,徐丽园,谭润鸾.藻酸双酯钠对肺炎病儿细胞黏附分子表达的影响[J].青岛大学医学院学报,1999,35(1). |
| 作者姓名： | 刘成玉 张银亭 徐丽园 谭润鸾 |
| 作者单位： | 1. 青岛医学院诊断学教研室,青岛,266021 2. 青岛医学院德育学教研室 3. 青岛市第二人民医院儿科 |
| 摘 要： | 目的探讨藻酸双酯钠（ＰＳＳ）对肺炎病儿细胞黏附分子表达的影响。②方法采用ＥＬＩＳＡ法，检测了应用ＰＳＳ治疗前后肺炎病儿外周血白细胞ＣＤ１８的表达、血清可溶性细胞间黏附分子－１（ｓＩＣＡＭ－１）和可溶性血管细胞间黏附分子－１（ｓＶＣＡＭ－１）浓度的变化。③结果肺炎病儿外周血白细胞ＣＤ１８表达、ｓＩＣＡＭ－１和ｓＶＣＡＭ－１浓度明显增高，与对照组比较差异均有极显著性（ｔ＝６．２７０～９．８８２，Ｐ均＜０．００１）。应用ＰＳＳ治疗后白细胞ＣＤ１８表达、ｓＩＣＡＭ－１和ｓＶＣＡＭ－１明显降低，与治疗前和普通治疗组比较差异均有极显著意义（ｔ＝７．５５２～６９．９３０，Ｐ均＜０．００１）。④结论ＰＳＳ能明显降低肺炎病儿细胞黏附分子表达。 |
| 关 键 词： | 藻酸双酯钠 细胞黏附分子 肺炎 儿童 |
THE EFFECTS OF POLYSACCHARIDE SULFATE ON THE EXPRESSION OF CELL ADHESION MOLECULES IN CHILDREN WITH PNEUMONIA |
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| Liu Chengyu,Zhang Yinting,Xu Liyuan,et al\.THE EFFECTS OF POLYSACCHARIDE SULFATE ON THE EXPRESSION OF CELL ADHESION MOLECULES IN CHILDREN WITH PNEUMONIA[J].Acta Academiae Medicinae Qingdao Universitatis,1999,35(1). | |
| Authors: | Liu Chengyu Zhang Yinting Xu Liyuan et al\ |
| Institution: | Liu Chengyu,Zhang Yinting,Xu Liyuan,et al\ Department of Diagnostics,Qingdao Medical College,Qingdao 266021\ |
| Abstract: | \ Objective \ To explore the effects of polysaccharide sulfate(PSS) on the expression of cell adhesion molecules in children with pneumonia.\ Methods \ By using enzymelinked immunosorbent assay(ELISA), the leukocyte CD18 expression, the concentrations of serum soluble intercellular adhesion molecule1(sICAM1) and soluble vascular cell adhesion molecule1(sVCAM1) were measured in children with pneumonia before and after treatment with PSS. \ Results \ The leukocyte CD18 expression, sICAM1 and sVCAM1 concentrations were significantly higher in pneumonia children than those in controls(t=6.270-9.882, P<0.001), and these indicators in pneumonia children after treatment with PSS were significantly lower than those before treatment and those with common treatment(t=7.552-69.930, P<0.001).\ Conclusion \ PSS could markedly decrease the expression of cell adhesion molecules in children with pneumonia. \ |
| Keywords: | polysacchride sulfate cell adhesion molecules pneumonia children |
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