外照射慢性放射病的胸腺肽治疗及追踪观察

目的本文观察１１例慢性放射病的胸腺肽治疗结果及病程转归。方法以临床症状变化、造血系统造血功能、Ｔ淋巴细胞百分率、染色体畸变率变化作为慢放病恢复的综合判断标准进行分析。结果胸腺肽能促使患者的无力型神经衰弱征候群明显好转；能显著提高Ｔ淋巴细胞百分率，进而增强机体免疫力，治愈口腔粘膜溃疡。追踪观察表明，慢放病恢复时间依次为细胞免疫功能（２年），无力型神经衰弱综合症（３．５年），造血组织造血功能（５～８年），染色体畸变率（１０年）。结论按照我们拟定的慢放病恢复综合判断标准，慢放病是一种可以恢复的职业性疾病。胸腺肽有助于慢放病的治疗，且方法简单，值得临床试用

Long term follow up observation of patients with chronic radiation sickness due to external irradiation treated with thymopeptide

Objective To provide the clinical data and prognosis judgement, we observed the results and progression of 11 cases of chronic radiation sickness due to external irradiation treated with thymopeptide.Methods The clinical symptoms, hematopoiesis, T lymphocyte percentage and chromosome aberration rate were used as the judgement indexes for recovery from the chronic radiation sickness.Results Thymopeptide treatment greatly improved the neurasthenic syndrome and increased the T lymphcyte percentage(P<0.05), which could enhance the patients' cellular immunity and cure ulcerative stomatitis.The follow up observation showed that cellular immunity returned to normal level after 2 years(P>0.05), and improvement of neurasthenic syndrome occurred 3.5 years after they left radiation work or diminished the exposure level.5 to 8 years after, bone marrow hematopoiesis also restored to the normal level.However, the chromosome aberration rate restored to the normal level 10 years after.Conclusion According to our judgement criteria, the chronic radiation sickness due to external radiation exposure can recover and thymopeptide is a helpful and simple means to treat it.