职业性噪声对暴露人群外周血中去甲肾上腺素及心血管系统的影响

目的研究职业性噪声对作业工人血清中去甲肾上腺素（NE）含量以及相关心血管系统指标的影响。方法选取某企业接触职业性噪声的职工130人作为噪声暴露组,另选该企业不接触噪声和其他毒物的134名职工为对照组,抽取空腹静脉血,采用酶联免疫法（ELISA）测定其外周血中NE的含量,按照《职业健康监护管理办法》进行职业性噪声暴露人群的健康检查。结果暴露组和对照组的NE含量分别为（0．1387±0．099）ng／ml和（0．1019±0．080）ng／ml,差异有统计学意义（P〈0．05）;血压、心率以及心电图异常的检出率差异也有统计学意义（P〈0．05）。结论职业性噪声可引起暴露人群外周血中NE含量的升高,并可能通过此途径对心血管系统产生影响。

Effects of occupational noise exposure on norepinephrine in peripheral blood and cardiovascular system

OBJECTIVE: To study the effects of noise on bioactivity of norepinephrine (NE) and cardiovascular system. METHODS: A total of 130 workers exposed to the occupational noise in one enterprise were selected as noise exposure group, and 134 workers not exposed to the occupational noise and other poisons served as control group. Fasting venous blood was drawn to determine the content of NE in peripheral blood with ELISA. According to Occupational Health Surveillance Manage regulations, the occupational noise exposures crowd was examined. RESULTS: The average of NE in exposure group was (0.1387 +/- 0.099) ng/ml, and (0.1019 +/- 0.080) ng/ml in control group. There was significant difference in NE between exposure and control group. There was significant difference in the detection rate of BP, HR and ECG between exposure and control group. CONCLUSION: The occupation noise can increase the NE in peripheral blood, and maybe affects the cardiovascular system in this way.