SLE患者外周血中CD4＋CD25＋CD127^low/-标记的调节性T细胞与临床表现和实验室指标相关性研究

目的：探讨CD4＋CD25＋CD127low/-标记的调节性T细胞（Treg）在系统性红斑狼疮发病机制电的作用。方法：用流式细胞仪检测45例系统性红斑狼疮（SLE）患者和45例年龄、性别相匹配的健康志愿者外周血CD4＋T细胞中Treg的百分比，同时分析SLE患者外周血中的CD4＋CD25＋CD127low/-标记的Treg与其临床表现、实验室指标的相关性。结果：SLE患者外周血CD4＋T细胞中Treg百分比与健康对照组比较差异无统计学意义。在SLE患者中，Treg的百分比与抗核小体抗体呈正相关（r=0．299，P=0．046），有光敏感的SLE患者中Treg较无光敏感组增高（P=0．017），余均无统计学差异。结论：SLE患者外周血中以CD4＋CD25＋CD127low/-标记的Treg中可能因含有部分无免疫抑制活性的效应性T细胞而特异性差，因此可能不适合用于临床免疫抑制治疗。

Periphery CD4+CD25+CD127low/- Regulatory T Cells and Its Correlation with Clinical Manifestations and Laboratory Results in Patients with Systemic Lupus Erythematosus

Objective:To explore the role of CD4+CD25+CD127low/-regulatory T cells(Treg) in pathogenesis of systemic lupus erythematosus(SLE). Methods:Frequency of Treg in peripheral blood mononuclear cells of 45 SLE patients,as well as age and sex-matched healthy controls were detected through flow cytometry,and correlation between frequency of Treg and clinical manifestations and laboratory results in patients with SLE was analyzed. Results:There was no significant difference in the frequency of Treg between SLE pati...