24例硬化性萎缩性苔藓临床及病理分析

目的:分析24例硬化性萎缩性苔藓患者的临床、病理表现.方法:对我中心诊治的24例硬化性萎缩性苔藓患者的临床资料进行临床、病理、误诊及治疗情况的回顾性分析.结果:硬化性萎缩性苔藓多见于青年女性,以20～40岁多见,男女比例1:2,皮损好发于外阴;部分区域萎缩和部分区域增生的11例,占45.8%;外用他克莫司疗效好;早期误诊12例(占50%).结论:临床特点及组织病理学检查为诊断本病的依据,医务人员应加强对早期硬化性萎缩性苔藓的认识.

Lichen Sclerosus et Atrophicus: A Clinical and Pathological Analysis of 24 Cases

Objective：To analyze clinical and pathological data which would aid in proper diagnosis of 24 cases of lichen sclerosus et atrophicus. Methods：A retrospective study examining the clinical manifestations,pathology,misdiagnosis,and treatment of 24 patients with lichen sclerosus et atrophicus in our hospital. Results：Lichen sclerosus et atrophicus was found more frequently in young females,and in subjects between 20-40 years old.Ratio of male to female was 1∶2.Skin lesions occurred more commonly in vulva.Pathological examination showed partial proliferation with atrophy in 11 cases（45.8%）.Topical tacrolimus was effective for treatment.The rate of early stage misdiagnosis was 50%（12 cases）. Conclusion：A correct diagnosis of lichen sclerosis et atrophicus relies on clinical features and histopathologic changes.To prevent misdiagnosis,doctors should have a better understanding of early stage lichen sclerosus et atrophicus.