Parvalbumin: a key protein in early distal tubule NaCl reabsorption. |
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| Authors: | Miriam Zacchia Giovambattista Capasso |
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| Affiliation: | Giovambattista Capasso, Chair of Nephrology, Department of Internal Medicine, Second University of Naples, Padiglione 17, Policlinico Nuovo, Via Pansini 5, 80131 Napoli, Italy. |
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| Abstract: | | Summary of key findings | The cortical distal nephron is committed to the fine regulationof electrolytes and water balance. Several investigations haveaddressed the molecular mechanisms implicated in this process.The paper by Belge et al. [1] demonstrates the emerging roleof parvalbumin (PV) on distal tubule NaCl reabsorption. PV isa divalent cation buffering protein, exclusively expressed inthe early distal convoluted tubule (DCT1). The authors showsolid data suggesting a functional relationship between PV andthe thiazide-sensitive Na+-Cl– cotransporter (NCC), themain entry step for Na+ and Cl– through the apical membraneat this nephron site. PV–/– mice exhibit a salt-losingphenotype characterized by increased diuresis, kaliuresis andhigh aldosterone levels, a phenotype very similar, althoughnot
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| Keywords: | distal convoluted tubule Gitelman's syndrome Na+Cl- cotransport parvalbumin thiazide diuretics |
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