| 对生物可吸收聚乙丙交酯体外降解特性和强度维持的研究 |
| |
| 引用本文： | 王菲,周洪,王小鹏,邹敏.对生物可吸收聚乙丙交酯体外降解特性和强度维持的研究[J].口腔医学,2008,28(10). |
| |
| 作者姓名： | 王菲 周洪 王小鹏 邹敏 |
| |
| 作者单位： | 1. 西安交通大学附属口腔医院正畸科,西安,710004
2. 西安交通大学机械工程学院,西安,710049 |
| |
| 摘 要： | 目的研究聚乙丙交酯(PLGA)棒体外降解特性和强度维持,评估其作为可吸收正畸支抗种植钉材料的可行性。方法通过磷酸盐缓冲液体外水解实验,定期观察PLGA失重率、粘均分子量和强度的变化。结果水解的前24周,PLGA质量变化不大,随后质量减少加速;粘均分子量在降解的前12周下降较快,随后降解速度减慢;降解的24周内,弯曲强度和剪切强度均大于骨皮质强度。结论固态压缩法制成的PLGA棒具有较高的初始力学强度和强度维持时间,PLGA有望应用于可吸收正畸支抗种植钉的研制。
|
| 关 键 词： | 聚乙丙交酯 降解 生物可吸收 |
Study of degradation properties and strength retention of bioabsorbable polyglycolidelactide in vitro |
| |
| WANG Fei,ZHOU Hong,WANG Xiao-peng,ZOU Min.Study of degradation properties and strength retention of bioabsorbable polyglycolidelactide in vitro[J].Stomatology,2008,28(10). |
| |
| Authors: | WANG Fei ZHOU Hong WANG Xiao-peng ZOU Min |
| |
| Institution: | WANG Fei,ZHOU Hong,WANG Xiao-peng,ZOU Min.(Department of Orthodontics,Dental Hospital,Xi\'an Jiaotong University,Xi\' an 710004,China) |
| |
| Abstract: | Objective To study the degradation properties and strength retention of polyglycolidelactide(PLGA) in vitro and to evaluate the feasibility of PGLA used as a material of bioabsorbable orthodontical anchorage implant.Methods By hydrolyzing experiment in vitro of PBS solution,weightlessness rate,the change of molecular weight and strength were observed periodically.Results The change of weight wasn't evident during the first 24 weeks and then the change accelerated;molecular weight decreased quickly during th... |
| |
| Keywords: | polyglycolidelactide degradation bioabsorption |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
