Clinical and laboratory evaluation of hospitalized patients with severe ovarian hyperstimulation syndrome |
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| Authors: | Cunha-Filho João Sabino Samama Marise Fanchin Renato Righini Claudia Kadoch Isaac-Jacques Frydman René Olivennes François |
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| Affiliation: | 1. Gynecological Endocrinology Department, Jagiellonian University Medical College Krakow, Poland;2. Institute of Cardiology, Jagiellonian University Medical College, and John Paul II Hospital Krakow, Poland;1. Centro Scienze Natalità, Obstetrics and Gynecology Dept, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy;2. Division of Genetics and Cell Biology, Reproductive Sciences Lab, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy;3. Vita-Salute San Raffaele University, Via Olgettina 58, 20132 Milano, Italy;1. Instituto Valenciano de Infertilidad, Valencia, Spain;2. Extra Omnes Medicina e Salute Riproduttiva, Cattolica, Italy;3. Icahn School of Medicine at Mount Sinai and Reproductive Medicine Associates of New York, New York NY, USA;4. Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York NY, USA;5. Centre of Reproductive Medicine, Hôpital Foch, University Paris-Ouest, Suresnes, France;6. Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey;7. Anatolia IVF and Women''s Health Centre, Ankara, Turkey;8. Departamento de Ginecologia, Clinica Fertilidade e Vida, Campinas and Hospital Sirio Libanês, Sao Paulo, Brazil;9. Department of Reproductive Medicine, Dexeus University Hospital, Barcelona Spain;10. Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium;11. Faculty of Health, Aarhus University, Aarhus, Denmark;12. Reproductive Biology Associates, Atlanta GA, USA;13. G.EN.E.R.A. Centres for Reproductive Medicine Rome, Italy;14. IVI Madrid, Rey Juan Carlos University, IdIPAZ, Madrid, Spain;15. Merck KGaA, Darmstadt, Germany;p. Department of Development and Regeneration, University of Leuven (KU Leuven), Leuven, Belgium;q. The Fertility Clinic, Skive Regional Hospital, and Faculty of Health, Aarhus University, Aarhus, Denmark |
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| Abstract: | Ovarian hyperstimulation syndrome (OHSS) is an important complication of ovarian stimulation and IVF that enhances patients' morbidity. To evaluate any increased incidence of hospitalization from severe OHSS during 2000, this study analysed certain clinical, ultrasound and laboratory characteristics of hospitalized patients with severe OHSS. These studies were carried out on women undergoing IVF who were hospitalized because of severe OHSS between 1996 and 2000 at the Hôpital Antoine Béclère. Patients' ages and serum hormone concentrations were collected on day 3 of ovarian stimulation for various assays, and laboratory and ultrasound measurements taken during ovarian stimulation for IVF were compared. An increase was noted during last year in the frequency of the severe form of OHSS requiring hospitalization (0.9 versus 1.8%, P <0.05). Patients' ages and hormonal characteristics on day 3 of menstrual cycle, and laboratory and ultrasound variables were similar between the two groups. In addition, the increased incidence of OHSS during 2000 was not associated with any special laboratory or ultrasound parameter, and the policy of ovarian induction had not changed. It is essential to introduce a simple ovarian stimulation protocol providing acceptable IVF results with a minimum of risk. |
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