L-硝基精氨酸甲酯对实验性葡萄膜炎的影响

目的：观察一氧化氮（ＮＯ）含量含量在葡萄炎房东水及玻璃体中的变化及Ｌ－硝基精氨酸甲酯（Ｎ＾Ｇ－ｎｉｔｒｏ－Ｌ－ａｒｇｉｎｉｎｅ ｍｅｔｈｙｌ ｅａｒｔｅｒ，Ｌ－ＮＡＭＥ）的治疗效果。方法；采用兔眼玻璃２本内注射内毒素脂多糖（ＬＰＳ）制备葡萄膜炎模型，以检测房水蛋白浓度，结果：葡萄为房水及玻璃体及玻璃体中显著增高，即刻使用Ｌ ＮＡＭＥ；显著降低了ＮＯ水平，同时其蛋白浓度、细胞数目及组织炎症程度明显降

Effect of NG-nitro-L-arginine methyl ester on experimental uveitis

Objective: To evaluate the change of nitric oxide (NO) in the aqueous and vitreous humors in uveitis. Methods: Uveitis was induced in rabbits with injection of lipopolysaccharide(LPS) into vitreous cavity. Ocular inflammation was evaluated by measuring protein concentration and leukocyte number in the aqueous humors and by histopathologic examination. NO production concentration was measured in the same time. The effects was evaluated when L NAME was used at various times. Results: NO production level in aqueous and vitreous humor had increased significantly in uveitis; it decreased significantly when L NAME was used at 0 h. Protein concentration and leukocyte numbers and the inflammatory degree decreased significantly at the same time. It decreased slightly when L NAME was used at 6 h. Conclusion: NO takes part in the pathogenesis of uveitis. The development of uveitis is inhibited when L NAME is used at 0 h.