| 活性维生素D及其类似物对足细胞的保护作用 |
| |
| 引用本文： | 邹敏书,余健.活性维生素D及其类似物对足细胞的保护作用[J].临床儿科杂志,2012,30(1):93-96. |
| |
| 作者姓名： | 邹敏书 余健 |
| |
| 作者单位： | 广州军区武汉总医院儿科,湖北武汉,430070 |
| |
| 摘 要： | 1,25(OH)2D3产生不足是慢性肾脏病(CKD)的主要特征之一,不仅导致钙磷代谢异常及骨矿化障碍,而且加速肾疾病的进展。1,25(OH)2D3及其类似物可减轻CKD患者的蛋白尿,减轻动物模型足细胞的损伤、凋亡和脱落,促进裂孔隔膜蛋白的表达,维持肾小球滤过屏障的完整性。1,25(OH)2D3保护足细胞机制与抑制足细胞肾素-血管紧张素系统、阻断Wnt/β-Catenin和转化生长因子(TGF)-β1信号通路有关。
|
| 关 键 词： | 维生素D 足细胞 慢性肾疾病 |
Podocytes as target of 1,25-dihydroxyvitamin D3 and its analogs Reviewer: |
| |
| ZOU Min-shu,YU jian.Podocytes as target of 1,25-dihydroxyvitamin D3 and its analogs Reviewer:[J].The Journal of Clinical Pediatrics,2012,30(1):93-96. |
| |
| Authors: | ZOU Min-shu YU jian |
| |
| Institution: | 1.Department of Pediatrics,Wuhan General Hospital of Guangzhou Command,Wuhan 430070,Hubei,China;2.Department of Pediatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China) |
| |
| Abstract: | 1,25(OH)2D3 deficiency is a prominent feature of chronic kidney diseases(CKD).It not only leads to abnormalities of calcium and phosphorus metabolism and bone mineralization in CKD patients,but also accele-rates the progression of kidney disease.It has been found that 1,25(OH)2D3 and its analogs can reduce proteinuria in CKD patients,ameliorate podocyte injury and loss,promote the expression of slit diaphragm proteins,and maintain the integrity of the glomerualr filtration barrier in animal models.The mechanisms of 1,25(OH)2D3 and its analogs protecting podocyte involve inhibiting rennin-angiotensin system and blocking Wnt/β-catenin and TGF-β1 signaling pathways in podocytes. |
| |
| Keywords: | vitamin D podocyte chronic kidney disease |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
