阿托伐他汀不良反应及合理应用

目的对临床一线调脂药阿托伐他汀所致药品不良反应(ADR)进行分析,为临床合理用药提供参考。方法文献检索2001年6月—2011年6月国内医药期刊报道的有关阿托伐他汀的不良反应案例,共收集34例,进行统计分析和归纳。结果 34例不良反应临床表现以肌损害最常见(47.06%),其次是肝-胆异常(29.41%),老年患者(≥61岁)发生率较高(64.71%)。结论多种药物合用是导致阿托伐他汀不良反应的重要危险因素。提示应注意药物相互作用,加强用药监测,以减少或避免ADR的发生。

Adverse Drug Reactions Caused by Atorvastatin and Clinical Rational Use

Objective To analyze the adverse drug reactions（ADR） caused by atorvastatin to offer the references for clinical rational use.Methods 34 cases of ADR induced by atorvastatin reported in domestic medical journals duing the period of 2001.6~2011.6,And statistical analysis was made.Results In 34 cases of ADR,Muscular damage was the commom clinical manifestation（47.06%）,Followed by liver and biliary abnormal（29.41%）,The risk factors of highter incidence rate were elderly pations（≥61 years old）.Conclusion The drug combination are very important risk factors of ADR caused by atorvastatin.It is suggested that attention to drug interaction and strengthen medication monitoring to reduce or avoid the recurrence of ADR.