肺癌患者血清Survivin和VEGF的表达及其临床意义

目的 通过检测Survivin和VEGF在非小细胞肺癌患者血清中的含量,探讨非小细胞肺癌诊断、分级的临床意义.方法 采用酶联免疫吸附法(ELISA)对51例非小细胞肺癌患者血清中Survivin和VEGF的表达水平及30例正常健康人血清Survivin和VEGF水平进行检测.结果 非小细胞肺癌患者血清Survivin和VEGF水平明显高于健康对照组(P＜0.01)；Survivin 和VEGF的表达呈正相关(P＜0.01)；Survivin和VEGF的表达与患者性别、年龄、肿瘤分期、病理分型、淋巴结转移等无关(P＞0.05).结论 检测非小细胞肺癌患者血清Survivin和VEGF的水平,对病情的发生和发展、具有重要的临床意义.

Significance of serum survivin and VEGF levels in lung cancer

Objective To detect the serum survivin and VEGF levels in non-small cell lung cancer patients and to explore the diagnosis and classification of non-small cell lung cancer.Methods The survivin and VEGF levels in 51 non-small cell lung cancer patients and 30 healthy controls were detected by ELISA.Results Levels of survivin and VEGF in non-small cell lung cancer patients significantly increased compared to the healthy controls(P<0.01),and the contents between survivin and VEGF were positively correlated(P<0.01).The expression of survivin and VEGF unrelated to clinical data such as patients’ gender,ages,tumor staging,tumor histopathological features,and lymph nodes metastasis(P>0.05).Conclusion The detection of survivin and VEGF in non-small cell lung cancer patients has an important clinical significance in studying the occurrence and progress,clinical diagnose of lung cancer.