| 甘草提取物缓释微丸制备体外释放考察 |
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| 引用本文： | 李俊松,冯怡,徐德生.甘草提取物缓释微丸制备体外释放考察[J].中国实验方剂学杂志,2007,13(10):11-14. |
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| 作者姓名： | 李俊松 冯怡 徐德生 |
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| 作者单位： | 上海中医药大学,上海,201203 |
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| 基金项目： | 上海市科委资助项目“芍药甘草复方释药系统基础研究”(No:04DZ19841) |
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| 摘 要： | 目的:制备甘草提取物缓释微丸,考察不同包衣条件下甘草提取物缓释微丸的体外释放。方法:采用单因素实验优选包衣工艺。结果:以丙烯酸树脂Eudragit RL100为包衣材料,包衣增重5%(w.w-1),增塑剂的用量为10%(w.w-1),可满足12 h缓释的要求。结论:包衣量、PEG6000量是影响药物释放的关键因素。
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| 关 键 词： | 缓释包衣微丸 甘草提取物 丙烯酸树脂 |
| 文章编号： | 1005-9903（2007）10-0010-04 |
| 收稿时间： | 2006-12-04 |
| 修稿时间： | 2006年12月4日 |
The Preparation and Drug Release Test of Glycyrrhizae Extracts Coated Sustained Release Pellets |
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| LI Jun-song,FENG Yi,XU De-sheng.The Preparation and Drug Release Test of Glycyrrhizae Extracts Coated Sustained Release Pellets[J].China Journal of Experimental Traditional Medical Formulae,2007,13(10):11-14. |
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| Authors: | LI Jun-song FENG Yi XU De-sheng |
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| Institution: | Shanghai University of Tradional Chinese Medicine,Shanghai 201203,China |
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| Abstract: | Objective:To prepare glycyrrhizae extracts coated sustained release pellets and study the drug release in vitro under different coating conditions.Methods:A single factor design experiment was applied to optimize the formulation of coated sustained release pellets.Results:A satisfactory 12 h sustained release curve can be obtained when the pellets is coated with Eudragit RS100 5%(w·w-1) and PEG6000 10%(w·w-1) under the optimized formulation.Conclusions:The increased weight and proportion of Eudragits RS100 and PEG6000 are the main factors which influence the drug release. |
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| Keywords: | coated sustained release pellets glycyrrhizae extracts eudragit |
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