|
|||||
|
|
Acute tryptophan pretreatment protects against behavioral changes caused by cerebral ischemia |
|
| Authors: | J M Carney |
| Affiliation: | 1. School of Safety and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, China;2. Institute of Yellow River Delta Earth Surface Processes and Ecological Integrity, Shandong University of Science and Technology, Qingdao, China;3. Qingdao Key Laboratory of Green and Low Carbon Biofilm and Water Environment Restoration, Qingdao SPRING Water Treatment Co., Ltd., Qingdao 266510, China |
| Abstract: | Male gerbils (Meronies ungulata) were treated with various doses of tryptophan and the changes in spontaneous motor activity determined. Tryptophan decreased behavior at a dose of 200 mg/kg. Cerebral ischemia was produced by bilateral carotid occlusion for 5 min. This duration of ischemia produced a large increase in activity at both 6 h and 24 h postischemia. Tryptophan (200 mg/kg) prevented the ischemia-induced increases in locomotor activity. These data suggest that dietary amino acids may play a role in determining the effects of ischemia. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |