精神分裂症自杀未遂者脑源性神经营养因子研究

目的:探讨影响精神分裂症自杀未遂患者脑源性神经营养因子(BDNF)水平的相关因素。方法:采用横断面病例-对照研究设计。研究包括精神分裂症自杀未遂组20例,精神分裂症无自杀行为组28例,正常对照组30名。采用酶联免疫吸附试验法测定血清BDNF浓度。采用简明精神病评定量表(BPRS)和自杀意图自评量表(SIOSS)对患者组进行评定。比较各组BDNF水平及其与相关因素之间的关系。结果:三组间BDNF水平差异有统计学意义(F=32.395,P<0.01)。Post-hoc分析发现,精神分裂症自杀未遂组BDNF水平(51.3±11.1)pg/ml]显著低于精神分裂症无自杀行为组(67.7±20.8)pg/ml](P<0.05),而精神分裂症无自杀行为组BDNF水平也低于正常对照组(111.3±39.0)pg/ml](P<0.01)。自杀未遂组的血清BDNF水平与自杀严重程度呈负相关(r=-0.836,P<0.01)。结论:精神分裂症自杀未遂患者BDNF水平低于精神分裂症无自杀行为患者和正常人群;BDNF可能是参与精神分裂症自杀病理生理机制的一种重要物质。

Serum level of brain-derived neurotrophic factor in schizophrenic patients with unsuccessful suicide at tempt

Objective:To investigate the related factors contributing to the serum level of brain-derived neurotrophic factor(BDNF)in schizophrenic patients with unsuccessful suicide.Method:Cross-sectional case-control study design.The study examined serum BDNF levels in 20 schizophrenic patients who had recently attempted suicide,28 non-suicidal schizophrenic patients and 30 healthy controls.The serum level of BDNF was detected with Sandwich ELISA.The brief psychiatric rating scale(BPRS)and the self-rating idea of sui...