| 卡维地洛在健康人体的生物等效性 |
| |
| 引用本文： | 夏素霞,唐思,王月敏,张士良,黄栋才,张文龙.卡维地洛在健康人体的生物等效性[J].中国临床药理学杂志,2009,25(3). |
| |
| 作者姓名： | 夏素霞 唐思 王月敏 张士良 黄栋才 张文龙 |
| |
| 作者单位： | 1. 辽宁省中医药研究院临床药理实验室,沈阳,110034
2. 合肥合源医药科技有限公司,合肥,230088 |
| |
| 摘 要： | 目的 研究中国健康志愿者单次口服卡维地洛片(抗高血压药)的药代动力学.方法 20名健康志愿者随机分成2组,分别单次口服试验与参比卡维地洛20 mg.用LC-MS法测定给药后不同时间点血浆中的卡维地洛浓度,并用DAS Ver 2.0软件计算其药代动力学参数.结果 卡维地洛试验与参比制剂主要药代动力学参数如下:tmax分别为(0.69±0.24)和(0.76±0.39)h,t1/2分别为(7.21±5.10)和(7.99±4.70)h,Cmax分别为(63.70±21.45)和(60.02±22.34)μ·L-1,AUC0-t分别为(161.98±62.24)和(168.15±64.09)μg·h·L-1,AUC0-∞分别为(173.30±78.42)和(179.49±72.84)μg·h·L-1;卡维地洛的相对生物利用度为(99.3±25.9)%.结论 2种制剂具有生物等效性.
|
| 关 键 词： | 卡维地洛片 药代动力学 液相色谱.质谱 |
Bioequivalence of carvedilol in healthy volunteers |
| |
| XIA Su-xia,TANG Si,WANG Yue-min,ZHANG Shi-liang,HUANG Dong-cai,ZHANG Wen-long.Bioequivalence of carvedilol in healthy volunteers[J].The Chinese Journal of Clinical Pharmacology,2009,25(3). |
| |
| Authors: | XIA Su-xia TANG Si WANG Yue-min ZHANG Shi-liang HUANG Dong-cai ZHANG Wen-long |
| |
| Institution: | 1.Laboratory of Clinical Pharmacology;Academe of Traditional Chinese Medicine of Liaoning Province;Shenyang 110034;China;2.Hefei Con-Source Medicine Technology Corp.;Hefei 230088;China |
| |
| Abstract: | Objective To study the pharmacokinetics of a single dose carvedilol tablets in Chinese healthy volunteers.Methods Twenty healthy volunteers were divided into 2 groups.Twenty mg single oral dose of carvedilol tablets was given to 20 healty volunteers.The concentrations of plasma samples collected from the volunteers respectively were determined by LC-MS.The pharmacokinetic parameters were calaulated by DAS Ver 2.0 software.Results The main pharmacokinetic parameters of carvedilol test and reference tablets w... |
| |
| Keywords: | carvedilol tablets pharmacokinetic LC-MS |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
