| 尾叶香茶菜二萜类化合物抑制肝癌细胞增殖作用的初步研究 |
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| 引用本文： | 纪海婷,王岩,马志明,李洪岩. 尾叶香茶菜二萜类化合物抑制肝癌细胞增殖作用的初步研究[J]. 吉林医学, 2008, 29(19): 1608-1610 |
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| 作者姓名： | 纪海婷 王岩 马志明 李洪岩 |
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| 作者单位： | 吉林大学第二医院，北华大学医学部，吉林大学，吉林大学基础医学院病理生理学教研室 |
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| 摘 要： | 目的：观察尾叶香茶菜中提取的六种二萜类化合物对人肝癌细胞株SMMC-7721的作用。方法：通过体外细胞培养并应用MTF法分析二萜类化合物对细胞存活率的影响。结果：二萜类化合物B、C、F可明显抑制SMMC-7721细胞增殖，且呈时间剂量依赖性。结论：本研究证明尾叶香茶菜来源的二萜类化合物具有抗肿瘤活性，为尾叶香茶菜的开发利用提供了翔实的实验依据。
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| 关 键 词： | 二萜类化合物 尾叶香茶菜 肝癌 |
Primary research of the offects of deterpenoids inducing apoptosis of hepatoma carcinoma cell |
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| JI Hai-ting,WANG Yan,MA Zhi-ming,et al. Primary research of the offects of deterpenoids inducing apoptosis of hepatoma carcinoma cell[J]. Jilin Medical Journal, 2008, 29(19): 1608-1610 |
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| Authors: | JI Hai-ting WANG Yan MA Zhi-ming et al |
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| Affiliation: | JI Hai -ting,WANG Yan,MA Zhi -ming,et al (The Second Hospital of Jilin Vniversity,Changchun,130041 ,China) |
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| Abstract: | Objective To determine the apoptosis of human hepatoma carcinoma cell line SMMC-7721 induced by six kinds of deterpenoids.Method The apoptotic rate of SMMC-7721 cells was detected by MTT and the cell cultured in vitro.Results Diterpenoid B,C and F could induce the apoptosis of SMMC-7721 in a dose-and time-dependent manner.Conclusion Diterpenoid B,C and F can trigger the apoptosis of SMMC-7721 through oxidative stress pathway, providing full and accurate experimental basis for using Rabdosia excise. |
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| Keywords: | Diterpenoid Rabdosia excise Hepatoma carcinoma |
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