Production, quality control and pharmacokinetic studies of Ho-EDTMP for therapeutic applications |
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| Authors: | Bahrami-Samani Ali Bagheri Reza Jalilian Amir R Shirvani-Arani Simindokht Ghannadi-Maragheh Mohammad Shamsaee Mojtaba |
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| Affiliation: | 1 Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Postal code: 14155-1339, Iran;2 Faculty of Nuclear Engineering and Physics, Amir Kabir University, Tehran, Iran |
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| Abstract: | 166Ho-EDTMP is a major therapeutic agent which is widely used in bone palliation therapy. In this study, a 166Ho-EDTMP complex was prepared successfully using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 ncm−2s−1) of natural Ho(NO3)3 samples (specific activity = 3–5 GBq/mg), dissolved in acidic media. The radiochemical purity of 166Ho-EDTMP was checked by ITLC (>99%) and stability studies in presence of human serum and final preparation were performed. The biodistribution of 166Ho-EDTMP and 166HoCl3 in wild-type rats was checked by scarification. SPECT imaging of 166Ho-EDTMP was also performed in wild-type rats. A comparative accumulation study for 166Ho-EDTMP and 166HoCl3 was performed for vital organs up to 48h. Significant bone accumulation (>70%) of the tracer in 48h was observed. |
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| Keywords: | Holmium-166 EDTMP Radiopharmaceutical therapy Biokinetic |
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