| α-1b干扰素(赛若金)对重症肝炎恢复期患者的影响 |
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| 引用本文： | 吴静黎,李韶光.α-1b干扰素(赛若金)对重症肝炎恢复期患者的影响[J].中国药房,2002,13(1):39-40. |
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| 作者姓名： | 吴静黎 李韶光 |
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| 作者单位： | 广东省惠州市，中心人民医院,惠州市，516001 |
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| 摘 要： | 目的 :探讨α-1b干扰素对重症肝炎向坏死后性肝硬化发展过程的影响。方法 :观察治疗组及对照组治疗前、后血清肝纤维化标志物、肝功能的变化。结果 :(1)治疗组治疗后血清肝纤维化标志物均下降 ,与治疗前比较有显著性差异 (P<0 01) ;对照组治疗前、后血清肝纤维化标志物变化无明显差异 (P>0 05)。 (2)治疗前、后肝功能比较 ,治疗组血清白蛋白及球蛋白、血小板水平回复至正常水平 ,且与对照组比较有显著性差异 (P<0 05)。结论 :α-1b干扰素对重症肝炎向坏死后性肝硬化发展具有阻逆作用。
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| 关 键 词： | α-1b干扰素 重症肝炎 血清学 肝纤维化标志物 |
| 文章编号： | 1001-0408(2002)01-0039-02 |
| 修稿时间： | 2001年10月25 |
Effects of α - 1bIFN on Hepatitis Gravis Reconvalescent |
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| WU Jingli,LI Shaoguang.Effects of α - 1bIFN on Hepatitis Gravis Reconvalescent[J].China Pharmacy,2002,13(1):39-40. |
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| Authors: | WU Jingli LI Shaoguang |
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| Abstract: | OBJECTIVE:To probe into the effects of α-1bIFN on the development process from the hepatitis gravis to postnecrotic cirrhosis.METHODS:The change of serum liver fibrosis markers and hepatic function were observed in treatment group and control group before and after treatment.RESULTS:(1)In treatment group,all the serum liver fibrosis markers were decreased after treatment and were significantly different from those in control group(P<0.01).In control group,there were no marked changes of markers before and after treatment(P>0.05).(2)After treatment,the levels of serum albumin,globulin and count of platelet reverted to normal in treatment group and the levels were significantly different from those in control group(P<0.05).CONCLUSION:α-1bIFN could repress the development of hepatitis gravis to postnecrotic cirrhosis. |
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| Keywords: | bIFN hepatitis gravis serology liver fibrosis marker |
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